What is Ephedrine Hydrochloride (Hcl)?
Ephedrine Hydrochloride (Hcl) is a central nervous system stimulant used to treat breathing problems (as a bronchodilator), nasal congestion (as a decongestant), low blood pressure problems (orthostatic hypotension), or myasthenia gravis. Ephedrine is also used to treat narcolepsy, menstrual problems (dysmenorrhea), or urine-control problems. Ephedrine is available in generic form.
How is Ephedrine supplied?
powder and oral tablet 30mg.
Mode of action of Ephedrine Hydrochloride (Hcl)
Ephedrine and pseudoephedrine are sympathomimetic alkaloids, which have a direct stimulatory effect on the vegetative nervous system and the central nervous system. These substances have an action α and β agonist and act by stimulating the release of endogenous catecholamines (norepinephrine, adrenaline, dopamine) in postganglionic sympathetic fibers.
The sympathetic α and β receptors are membrane receptors sensitive to catecholamines and are found in most cells of the human body including the heart, lungs and blood vessels.
In addition, ephedrine is an indirect adrenergic receptor agonist, as it increases the bioavailability and action of norepinephrine at the cerebral and cardiac levels.
To go a little further, Ephedrine is not used by athletes to stimulate the central nervous system, increase self-confidence, reduce fatigue. It is used in sports such as athletics, boxing, football, rugby.
For years, Ephedrine Hydrochloride (Hcl) has been touted as a stimulator of weight loss. On the other hand, in view of the numerous undesirable effects reported, the FDA (Food and Drug Administration) has suggested recommendations for the use and sale of these dietary supplements: the maximum dose per dose of 8 mg and the maximum daily dose of 24 mg. Not to mention the warning about prolonged or concomitant use with caffeine.
It must be remembered that ephedrine should not be administered to patients on MAOI antidepressant treatment or who have stopped treatment for the past 15 days, since their association may cause fatal hypertension. Also, ephedrine-based drugs are contraindicated in narrow-angle glaucoma, coronary artery disease, hypertension, renal failure, arrhythmias, and in patients who have had a stroke. brain.
Scientific studies in support
In the 2000s, a seemingly healthy student died after consuming an energy drink containing ephedrine. This was demonstrated by autopsy which revealed myocardial necrosis related to the toxicity of ephedrine. Blood and urine concentrations showed that death was not caused by acute poisoning due to overdose but is the result of regular and prolonged consumption
Of course, several other cases of death have been reported
in a subject with cerebral vasculopathy, ephedrine triggered intracranial hemorrhage;
A 44-year-old woman who replaced her daily coffee and chocolate doses with ephedrine suffered a cardiovascular arrest and the autopsy revealed deep thrombus of the left anterior coronary artery.
spinning sensation (vertigo),
loss of appetite,
sleeping disorder (insomnia),
fast heart rate,
weight loss, and difficult or painful urination.
The dosage of Ephedrine is based on the patient’s medical condition and response to therapy. For prescription Ephedrine, do not exceed 150 mg per day in adults or 75 mg per day in children. Ephedrine may interact with other adrenalin-like drugs, MAO inhibitors, beta-blockers, blood pressure medicine, tricyclic antidepressants, diuretics (water pills), digoxin, atropine, theophylline, oxytocin, or St. John’s wort. Tell your doctor all medications you are taking. Ephedrine should be used only when prescribed during pregnancy. It is not known whether this drug passes into breast milk. Due to the potential risk to the infant, breastfeeding while using this drug is not recommended.
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